2 pH units) Embryos cultured in media containing a weak

2 pH units). Embryos cultured in media containing a weak

acid (5,5-dimethyl-2,4-oxazolidinedione; DMO) formed blastocysts with decreased cell number and inner cell mass number, as well as increased apoptosis, even though blastocyst development and morphology were unchanged. Interestingly, the effects were similar regardless of whether the pH stress was present for a short-term ‘acute’ exposure (during the zygote to 2-cell, or 2-cell to 8-cell division) or an extended ‘chronic’ period of time (continually from the zygote to the blastocyst stage). Exposure to DMO during the first cleavage division did not alter implantation; NVP-LBH589 however, fetal weight and crown rump length were significantly decreased (P < 0.05). In contrast, continuous exposure to DMO throughout preimplantation development reduced not only implantation but also fetal weight and crown rump length. This study highlights the importance of correct intracellular pH and demonstrates that slight deviations can significantly impact embryo development and viability. (C) 2010, Reproductive Healthcare Ltd. Published by Elsevier Ltd. All rights reserved.”
“Aims To test the null hypothesis that bony pelvis

dimensions are similar in women with and without stress urinary incontinence (SUI), Bcl-2 inhibition both in the postpartum and midlife periods. Methods Secondary analyses were GSK1210151A performed of two casecontrol studies comparing women with SUI to asymptomatic controls. One study examined primiparas in the first 912 months postpartum; the other study involved middle-aged women. SUI was confirmed by full-bladder stress test. All subjects underwent pelvic magnetic resonance

imaging. The interspinous and intertuberous diameters, subpubic angle, and sacrococcygeal joint-to-the inferior pubic point distance were measured from the images independently by two authors. Results In the young cohorts, we compared primiparas with de novo postpartum SUI to both continent primiparas and nulliparas. Postpartum SUI is associated with a wider subpubic angle. There is also a trend towards wider interspinous and intertuberous diameters in the stress-incontinent primiparas as compared to the continent cohorts, although this did not reach statistical significance with our sample sizes. By contrast, no significant differences in bony pelvis dimensions were identified when comparing middle-aged women with SUI and their continent controls. Conclusions Bony pelvis dimensions are different in women with SUI than in matched continent controls. However, these differences are only identified in young primiparas in the postpartum period, not in middle-aged women. Neurourol. Urodynam. 32: 3742, 2013. (c) 2012 Wiley Periodicals, Inc.

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