In conclusion, mitral valve replacement with an on-pump beating heart technique via a right thoracotomy offers a safe

approach when excessive dissection is required to place a cross-clamp to the ascending aorta.”
“Intimate partner violence (IPV) is an important cause of women’s health and socio-familial severe problems, the most extreme being the victims’ homicide. This is the first nationwide Portuguese autopsy-based and judicial-proven study about female intimate partner homicide.\n\nAt SHP099 least 62 women over 15 years old were killed by current or former men-intimate partners, corresponding to an IPV-related female mortality rate of 0.44/100.000 women; intimate partner violence was the reason of homicide in 60.8% of all autopsied women.\n\nThe typical Portuguese victim showed to be a young adult woman, employed, killed by a current husband in a long-term relationship, usually with children in common and with a history of previous IPV. The typical Portuguese perpetrator showed to be older than the victim, employed, owning a firearm and without criminal records. At the time of the fatal event 59.7% of the relationships were current.

In 57.9% of the former relationships women were killed during the 1st year after its terminus. Near half of the perpetrators attempted or committed suicide afterward. Most women were killed by gunshot wounds (45.2%), especially in the thorax (48.4%), with multiple fatal injuries; 56.5% also presented non-fatal injuries.\n\nThe detection of prior IPV and the risk evaluation seems to be fundamental Entinostat in vitro to decrease these fatal outcomes, but also, the prevention of perpetrators’ alcohol abuse and carrying weapons. This work emphasizes the need to deepen the

research on this issue, aiming to contribute to prevent both fatal and non-fatal IPV-related cases. (C) 2013 Elsevier Ltd and Faculty of Forensic and Legal Medicine. All rights reserved.”
“Collagen, a primary component of the extracellular matrix (ECM), is highly expressed in a variety of cancers and influences the GDC-0941 solubility dmso tumor microenvironment by increasing the recruitment of macrophages and endothelial cells. Therefore, collagen is a highly promising target for cancer therapy. The collagen-binding domain (CBD) can dynamically bind to collagen and achieve the sustained release of CBD-fused protein in the collagen network. Here, we developed a collagen-binding epidermal growth factor receptor (EGFR) antibody fragment for targeting the collagen-rich ECM in tumors. The single chain fragment variable (scFv) of cetuximab was fused to CBD (CBD-scFv) and expressed in Pichia pastoris. CBD-scFv preserved the antigen binding domain and anti-tumor activity of cetuximab in vitro. Moreover, CBD-scFv displayed a collagen binding ability due to the function of CBD.