AGD is delivered using a fingerless leather glove with a Velcro patch on the palmer aspect and the counter
Velcro patch adhered to the pig’s chest. Data (mean I SD) were analyzed using one-way ANOVA with pair wise multiple comparisons to assess differences between groups. p-Value <= 0.05 was considered significant.
Results: Tubastatin A ic50 Both AGD-CPR and AGD-CPR + ITD groups produced lower intrathoracic pressure (IttP, mmHg) during decompression phase (-13.4 +/- 6.7, p=0.01 and -11.9 +/- 6.5, p=0.01, respectively) in comparison to S-CPR (-0.3 +/- 4.2). Carotid blood flow (CBF, % of baseline mL/min) was higher in AGD-CPR and AGD-CPR + ITD (respectively 64.3 +/- 47.3%, p=0.03 and 67.5 +/- 33.1%, p=0.04) as compared with S-CPR (29.1 +/- 12.5%). Coronary perfusion pressure (CPP, mmHg) was higher in AGD-CPR and AGD-CPR + ITD (respectively 19.7 +/- 4.6, p = 0.04 and 25.6 +/- 12.1, p= 0.02) when compared to S-CPR (9.6 +/- 9.1). There was no statistically significant difference between AGD-CPR and AGD-CPR
+ ITD groups with reference to intra-thoracic pressure, carotid blood flow and coronary perfusion pressure.
Conclusion: Active compression decompression delivered by this simple and inexpensive adhesive glove device resulted in improved cerebral blood flow and coronary perfusion pressure. There was no statistically significant added effect of ITD use along with AGD-CPR on the decompression of the chest. (C) 2013 Elsevier Ireland Ltd. All rights reserved.”
“Purpose
Insulin-like growth factors (IGF) regulate a wide range of biological functions including cell proliferation, differentiation, and apoptosis selleckchem inhibitor through paracrine and autocrine mechanisms. Accordingly, the present study analyzed polymorphisms of IGF VE-822 mw genes and their impact on the prognosis for patients with colorectal cancer.
Materials and Methods
Four hundred and two consecutive patients with curatively resected
colorectal adenocarcinoma were enrolled in the present study. The genomic DNA was extracted from fresh colorectal tissue and 8 polymorphisms of IGF genes determined using a real-time polymerase chain reaction genotyping assay.
Results
Pathologic stages after surgery were as follows: stage 0/I (n=85, 21.1%), stage II (n=147, 36.6%), stage III (n=145, 36.1%), and stage IV (n=25, 6.2%). Multivariate survival analysis including stage, age, site of disease, and carcinoembryonic antigen level showed that the progression-free survival for patients with the IGF2 + 1280 GG genotype was slightly better than for the patients with the combined IGF2 + 1280 AA and AG genotype (p=0.056), although there was no significant difference in the overall survival. However, the other polymorphisms were not associated with survival.
Conclusion
None of the 8 IGF1 or IGF2 gene polymorphisms investigated in this study were found to be independent prognostic markers for Korean patients with surgically resected colorectal cancer.”
“Non-obstructive azoospermia is diagnosed in approximately 10% of infertile men.