Although associations with adenocarcinoma and progression to PSSs have been reported,5 our patient elected for close active surveillance with annual biopsies and routine PSAs. In the absence of signs of progression to prostatic sarcoma, we have not pursued workup for metastatic disease. To better identify the best treatment of STUMP, better characterization and longer follow-up are needed. As the number of these cases continues to accumulate, better understanding of this Anticancer Compound Library ic50 disease will be possible. “
“Behcet disease (BD), a vasculitic disease, may present with a broad range of systemic manifestations. Urologic complications are rarely described in the literature,

but when they occur, they present as epididymo-orchitis. We describe a rare case of testicular infarction in a patient with BD followed up with serial ultrasound imaging. We highlight the diagnostic challenges when presented with testicular pain in a patient with BD and the potential consequences in the management. A 36-year-old male patient presented with a 1-day history of left-sided scrotal pain. There were no urinary symptoms or fever. There was no recent preceding injury or trauma. He had similar episodes of left testicular pain diagnosed as epididymitis several years ago but had remained Selleckchem KPT330 well in the interim. His past medical history included a diagnosis of BD with scrotal and mouth ulcers and ocular involvement.

This was stable and treated with steroids, cyclosporine, colchicine, and azathioprine. Scrotal examination elicited tenderness of a swollen

left testicle. No mass was palpable. Hematology revealed raised white blood cell count at 16.4*109/L. Urine and microbiologic analyses were unremarkable. Germ cell tumor markers (lactate dehydrogenase, alpha-fetoprotein and human chorionic gonadotropin) were within normal range. He was clinically diagnosed with epididymo-orchitis, and oral ciprofloxacin and doxycycline were commenced. Ultrasound scan showed an isoechoic and well-defined abnormality in the upper pole of left testis, merging with a swollen and poorly defined epididymal head. This was a new finding compared with a previous ultrasound scan performed 4 years previously. Color Doppler assessment was unremarkable (Fig. 1). There was a wide differential 3-mercaptopyruvate sulfurtransferase for the nature of this lesion, including the incidental finding of a testicular tumor. After multidisciplinary input, a repeat testicular ultrasound scan was performed, which showed evolution of the testicular lesion becoming hypoechoic compared with the rest of the testis (Fig. 2). The patient was reviewed in outpatient clinic after 3 weeks when he reported improvement in his symptoms and resolution of the testicular pain. Owing to the relative lack of symptoms and the concern for testicular malignancy, possibility of orchidectomy was suggested.