Clinical response was determined by T class (an index of tumor size, p = 0.002), N class (lymph check details node metastasis, p = 0.007), M class (distant metastasis, p = 0.001) and disease stage (p < 0.001), but TNFRSF1B A1466G genotype was independent of these factors. Clinical response was significantly associated with overall survival (Figure 2), however, TNFRSF1B A1466G genotype had no effect on the overall survival, presumably because it was not associated with death within 1 year after the completion of chemoradiotherapy.

There is no report on the GSK2118436 mw function of this polymorphism but it has been reported that higher expression levels of TNFRSF1B gene in colorectal cancer specimens from responding patients were observed compared with those from non-responding patients [30]. Thus,

the polymorphism-dependent clinical response might be due to the polymorphism-dependent expression levels, although further studies are needed. Conclusions Genetic polymorphisms of the TNFRSF1B gene, M196R/T587G, A1466G and C1493T, were evaluated in Japanese ESCC patients treated with a definitive 5-FU/CDDP-based chemoradiotherapy. It was found that A1466G, but not M196R/T587G or C1493T, was a predictive factor of clinical response to chemoradiotherapy. BI-D1870 clinical trial Clinical response was predicted by TNM classes and disease stage, but A1466G genotype was independent of these factors. Further clinical investigation with a large number of patients or experiments in vitro should be performed to assess the predictive value of TNFRSF1B A1466G genotype after chemoradiotherapy. Acknowledgements This work was supported in part by a Grant-in-Aid for Scientific Research and

Service Innovation Program from the Ministry of Education, Culture, Sports, Science and Technology of Japan. References 1. Cooper JS, Guo MD, Herskovic A, Macdonald JS, Martenson JA Jr, Al-Sarraf M, Byhardt R, Russell AH, Beitler JJ, Spencer S, Asbell SO, Graham MV, Leichman LL: Chemoradiotherapy of locally advanced esophageal cancer: long-term follow-up selleck screening library of a prospective randomized trial (RTOG 85–01). Radiation Therapy Oncology Group. JAMA 1999, 281:1623–1627.PubMedCrossRef 2. Ohtsu A, Boku N, Muro K, Chin K, Muto M, Yoshida S, Satake M, Ishikura S, Ogino T, Miyata Y, Seki S, Kaneko K, Nakamura A: Definitive chemoradiotherapy for T4 and/or M1 lymph node squamous cell carcinoma of the esophagus. J Clin Oncol 1999, 17:2915–2921.PubMed 3. Kaneko K, Ito H, Konishi K, Kurahashi T, Ito T, Katagiri A, Yamamoto T, Kitahara T, Mizutani Y, Ohtsu A, Mitamura K: Definitive chemoradiotherapy for patients with malignant stricture due to T3 or T4 squamous cell carcinoma of the oesophagus. Br J Cancer 2003, 88:18–24.PubMedCrossRef 4. Tahara M, Ohtsu A, Hironaka S, Boku N, Ishikura S, Miyata Y, Ogino T, Yoshida S: Clinical impact of criteria for complete response (CR) of primary site to treatment of esophageal cancer. Jpn J Clin Oncol 2005, 35:316–323.PubMedCrossRef 5.