Conflict of interest A Postulka is an employee of Cepheid Europe. SD Goldenberg, KN Bisnauthsing, A Patel, D Wyncoll, GL French and R Schiff declare no conflict of interest.

Compliance with ethics guidelines All procedures followed were in accordance with the ethical standards of the responsible committee on human experimentation (London City and East Research Ethics Committee) and with the Helsinki Declaration of 1975, as revised in 2000 and 2008. Informed consent was obtained Wortmannin clinical trial from all patients for being included in the study. Open Access This article is distributed under the terms of the Creative Commons Attribution Noncommercial License which permits any noncommercial use, distribution, and reproduction in any medium, provided the original author(s) and the source are credited. Electronic

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