HRQL assessment has become one of the most widely used subjective health evaluations in chronic illness. Life experiences of HIV-infected people are as heterogeneous as the population affected. HRQL assessment in these patients provides valuable information about the effects of ART, disease progression and prognosis, and the factors that influence prognosis; results that clinical analysis is unable to provide. It must be taken into account that the evaluation of HRQL by the patient does OSI744 not necessarily coincide with the severity of the illness as defined by the patient’s doctor. HRQL provides valuable information for health care managers

and authorities, as it allows evaluation of the efficiency, effectiveness and cost–benefit ratio of health care programmes, and for pharmaceutical companies that gather data on effectiveness, clinical benefit, satisfaction with treatment and treatment adherence [9–11]. The literature shows the importance of factors most closely related to HRQL in HIV-infected people. These factors are psychological aspects and sociodemographic characteristics, clinical indicators unrelated to the infection and the individual illness [6,12–15]. HRQL in the HIV-infected population has not previously been investigated

in our region, and so the aim of this study was to determine the impact of various sociodemographic, clinical and psychological factors on HRQL in an HIV-infected population receiving care at the HIV clinic of a tertiary Spanish Osimertinib hospital, Arachidonate 15-lipoxygenase and to identify variables that allow us to establish a predictive model to evaluate HRQL in this population and these patients’ overall perception of their health status. A cross-sectional study

was conducted in HIV-infected patients under follow-up at the Río Hortega University Hospital in Valladolid (Spain). The target population comprised individuals with HIV infection who agreed to participate in the study in the period March 2007 to April 2008. Exclusion criteria were: (a) recent diagnosis with HIV infection (less than 6 months ago); (b) age <16 years; (c) the patient not being frequently seen by our specialists; (d) refusal to participate in the study; (e) a physical or mental condition that made interviewing the patient problematic. Nine persons refused to participate in the study (six men and three women) and did not sign the medical consent form; these patients were not a homogeneous group in terms of sociodemographic, epidemiological or clinical characteristics. Following consultation with the Investigation Department, a total of 150 out-patients were consecutively selected after they had signed the medical consent form according to the principles of the Declaration of Helsinki.