In a previous study, the presence of a new infarct was detected by CCT in 4% of patients with a TIA and was associated with the risk of stroke during a period of 90 days

after the TIA (Douglas et al. 2003). In the present study, 17 patients with a TIA (1.1%) suffered a stroke during hospitalization. We also determined that the early short-term risk of stroke was not associated with the evidence of a new infarct on the initial CCT scan. A previous study reported the risk of stroke to be about 4% among patients with a TIA who presented to hospital with a median time of 3 days (Dennis et al. 1990). The low frequency of stroke in the present Inhibitors,research,lifescience,medical study may be explained by early admission, hospitalization of patients, a comprehensive and rapid evaluation including all required diagnostic procedures, Inhibitors,research,lifescience,medical and early secondary prophylaxis. To the best of our knowledge, previous studies have not specifically evaluated the predictors of a new infarct on CCT in patients with a TIA. Other studies have investigated the relationship between cerebral infarction that is detected by CCT and long-term outcome and suggested that evidence of infarct

is correlated with an increase in the risk of recurrent stroke and mortality, but the association between stroke recurrence during hospitalization and infarcts Inhibitors,research,lifescience,medical evidence in patients with TIA Inhibitors,research,lifescience,medical has not been investigated previously (Evas et al. 1991; van Swieten et al. 1992; Gladstone et al. 2004). Obviously, the sensitivity of CCT to detect infarcts is considerably lower than that of other imaging techniques. For example, Fazekas et al. (Fazekas et al. 1996) detected a new infarct by MRI in 31% of patients with a TIA. Similarly, Inhibitors,research,lifescience,medical Prabhakaran et al. (Prabhakaran et al. 2011), using perfusion computed tomography, found perfusion 17-DMAG Phase 2 abnormalities in 33.8% of patients with a TIA. Previous research has also shown that the Palbociclib Phase 3 impact of CCT on visualizing

cerebral ischemia in patients with a TIA can be improved with CT perfusion imaging that can provide Entinostat comprehensive information rapidly (Smith et al. 2003). In summary, the CCT is less sensitive than MRI and diffusion-weighted imaging (DWI) in identification of new infarct in patients with TIA. In the present study, almost (96.9%) of patients did not show a new infarct on CCT. Several investigations, using DWI, demonstrated the frequency of abnormalities in patients with TIA from 41% to 68% that suggest that DWI is a preferable technique in verifying infarcts in patients with TIA and affords more precise detection of ischemic lesion compared to conventional CCT (Kidwell et al. 1999; Ay et al. 2002, 2005; Inatomi et al. 2004; Restrepo et al. 2004; Oppenheim et al. 2006). Our study has several limitations.