Steps that could be taken to minimize or eradicate bone morbidity, including measurement of bone mineral density at remedy onset, adequate calcium consumption, vitamin D and K supplementation, satisfactory sunlight exposure, weight bearing workout routines, fall prevention, avoidance of antiepileptic medication linked to osteopenia, and judicious use and option of glu cocorticoids and anticoagulants are recommended. Health-related therapy of osteo porosis related to cancer treatment in brain tumor patients working with bisphos phonates, teriparatide, and calcitonin is talked about, as well as kyphoplasty for symptomatic vertebral compression fractures. QL 14. SECONDARY ADRENAL INSUFFICIENCY Soon after GLUCOCORTICOID WITHDRAWAL IN BRAIN TUMOR Sufferers Arnaldo N. Da Silva and David Schiff, University of Virginia, Neurology Division, Division of Neuro Oncology, Charlottesville, VA, USA Glucocorticoids will be the principal drug utilised to regulate vasogenic edema in brain tumor patients.
Rapid glucocorticoid taper may possibly not just decompen sate intracranial strain but may well also unmask secondary adrenal insuffi ciency, some signs of which discover more here will be mistakenly attributable to greater intracranial pressure or unwanted side effects of chemotherapy and radiation therapy. 5 neuro oncology sufferers with clinical MK-2461 and laboratory evidence of sec ondary adrenal insufficiency had been identified from the University of Virginia Neuro Oncology Database from February 2002 to January 2006. Just about the most regular symptom uncovered among our patients was fatigue. High dose cosyn tropin check was utilized in all circumstances. All individuals showed speedy improvement of their signs and symptoms following glucocorticoid replacement. Though unusual, a healthful index of suspicion for this complication and use of pharmacologic testing will help avert misattribution of secondary adrenal insufficiency signs and symptoms and deleterious consequences.
QL 15. COGNITIVE Results OF MARIMASTAT IN Folks WITH Key BRAIN TUMORS Mercedes D. Dickinson1 and C. Meyers2, 1University of Houston, Houston, TX, USA, 2The University of Texas M. D. Anderson Cancer Center, Houston, TX, USA Treatment for principal brain tumors has evolved above the last twenty many years to incorporate advances in surgical treatment, radiation treatment method, bioimmunotherapy, and chemotherapy. These therapies are already intended to attack the tumor itself, with lesser degrees of concern regarding how they influence surrounding brain parenchyma. However, there continues to be a shift to examine the cogni tive results of these treatment options also. This research explored the cognitive results with the drug marimastat while in the therapy of persons with principal brain tumors. Marimastat is really a matrix metalloproteinase inhibitor which has been implicated in slowing tumor angiogenesis and metastasis by destroying the extracellular matrix of tumor cells required for invasion, intravasation, extravasation, and migration.