Methods: EMBASE, MEDLINE, EBM Reviews, dissertation abstract databases, and clinicaltrials.gov were searched. Two investigators independently reviewed
titles, abstracts and full texts in a hierarchical manner for study eligibility with a quadratic kappa score at each level. Two authors abstracted data independently and the quality of the articles was assessed using the five-point Jadad scale. Outcomes were termination of ventricular fibrillation (VF)/ventricular tachycardia (VT) at 5 s post shock (TOF), return of organized rhythm selleck compound (ROOR) and return of spontaneous circulation (ROSC).
Results: A total of 3281 potentially relevant citations were identified and, of these, eight papers were selected with Kappa values of 0.53 for titles, 0.71 for abstracts, and 0.94 for articles. Danusertib order Quality scores varied from 0 to 4/5. Biphasic first-shock success for all three outcomes of interest was similar regardless of energy levels, and uniformly superior to monophasic first-shock success. Median time to first shock varied across trials based on level of randomization (first responders versus advanced life support tiered response) and may contribute to observed differences. Lack of variability across two waveforms precluded a meta-analytical approach.
Conclusions:
This systematic review suggests that evaluated biphasic waveforms have similar first-shock success as measured by the three outcomes of interest and all are superior to monophasic shocks. (C) 2013 Elsevier Ireland Ltd. All rights reserved.”
“Background: Feature Tracking software offers
measurements of myocardial strain, velocities and displacement from cine cardiovascular magnetic resonance (CMR) images. We used it to record deformation parameters in healthy adults and compared values to those obtained by tagging.
Methods: We used TomTec 2D Cardiac Performance Analysis software to derive global, regional and segmental PND-1186 in vitro myocardial deformation parameters in 145 healthy volunteers who had steady state free precession (SSFP) cine left ventricular short (basal, mid and apical levels) and long axis views (horizontal long axis, vertical long axis and left ventricular out flow tract) obtained on a 1.5 T Siemens Sonata scanner. 20 subjects also had tagged acquisitions and we compared global and regional deformation values obtained from these with those from Feature Tracking.
Results: For globally averaged measurements of strain, only those measured circumferentially in short axis slices showed reasonably good levels of agreement between FT and tagging (limits of agreement -0.06 to 0.04). Longitudinal strain showed wide limits of agreement (-0.16 to 0.03) with evidence of overestimation of strain by FT relative to tagging as the mean of both measures increased.