On the other hand, in a-GeTe, BMS202 molecular weight Raman spectrum reveals Ge sites in tetrahedral and defective octahedral environment. We suggest that the structure of c-GeTe consists of highly distorted as well as defective Ge sites, which leads to the large concentration of intrinsic defects (vacancies). These random defects would act as topological
disorder in the lattice and cause the bands to develop tails at the band edges, a continuum of localized levels appearing in the gap. The present study deepens the understanding of the local atomic structure, influence of defects and its close relation to the phase-change mechanism. (C) 2011 American Institute of Physics. [doi:10.1063/1.3653265]“
“Nelfinavir is a potent HIV-protease inhibitor with pleiotropic effects in cancer cells. Experimental studies connect its anticancer effects to the suppression of the Akt signaling pathway, but the actual molecular targets remain unknown. Using a structural proteome-wide off-target pipeline, which integrates molecular
dynamics simulation and MM/GBSA free energy calculations with ligand binding site comparison and biological network analysis, we identified putative human off-targets of Nelfinavir and analyzed the impact on the associated biological processes. Our results suggest that Nelfinavir is able to inhibit multiple members of the protein kinase-like superfamily, which are involved in the regulation of cellular processes vital for carcinogenesis Prexasertib mouse and metastasis. The Tamatinib Fosdium computational predictions are supported by kinase activity assays and are consistent with existing experimental and clinical evidence. This finding provides a molecular basis to explain the broad-spectrum anti-cancer
effect of Nelfinavir and presents opportunities to optimize the drug as a targeted polypharmacology agent.”
“Purpose: The aim of this study was to compare the vascularized osteoperiosteal femur flaps (VFFs) and the nonvascularized femur grafts (NVFGs) for reconstruction of the mandibular defects of pigs.
Materials and Methods: Eight adult domestic pigs were used. The defects created in the mandibular angle were reconstructed with VFFs in 4 pigs (group 1) and NVFGs in the other 4 pigs (group 2). All the pigs were killed after 3 months of heating. Undecalcified and decalcified sections were prepared for histomorphometric analysis and histologic examination. Radiodensitometric absorptiometry was used to assess the differences in bone mineral density between the 2 groups.
Results: The bone volume to the total measured volume, trabecular thickness, and trabecular number were significantly greater in the VFF group than in the NVFG group (P < .05). However, the trabecular separation was significantly lower in the VFF group than the NVFG group (P = .029).