Rapid progression of disease in Uganda is associated with TNF-α-mediated inflammatory pathology. Invasive pulmonary aspergillosis.  The role of TNF-α and lymphotoxin-alpha (LT-α) in fungal infection diseases has been reported [64]. The presence of polymorphism in TNF-α and LT-α genes or their receptors might increase the susceptibility of haematologic patients to develop invasive pulmonary aspergillosis (IPA). SNPs in TNF-α, LT-α and tumour necrosis factor receptor 2 (TNFR2) and a variable number of tandem repeats (VNTRs) in TNFR2 were investigated in haematologic patients and controls. Similar genotype and alleles frequencies were detected between patients

and controls. TNF-α and LT-α polymorphisms were not associated with the presence of IPA. A strong high throughput screening association of IPA with VNTR in the promoter region of the TNFR2 gene was found. Cancer is the major health problem and leading cause of death. Several genetic polymorphisms have been reported to associated with disease. The genetic factors play important role in the epidemiology and pathogenesis of cancer. TNF genetic polymorphism

can regulate gene expression and have been associated with inflammatory and malignant conditions. Azmy et al. [65] have been detected the role of TNF-α rs1800630 and rs361525 INCB024360 cost polymorphisms in breast cancer susceptibility and severity. Breast cancer cases and controls have shown similar allele frequencies for both polymorphisms. No association was found between rs1800629, rs361525 and susceptibility to breast cancer in North European population. Role of TNF rs361525 in breast cancer risk was investigated by Gaudet et al. [66], in breast cancer cases and controls, in European, from 30 studies in the Breast Cancer Association Consortium. Jung et al. [67] have detected 12 SNPs in 11 apoptosis-related next genes in the apoptosis pathway. Human papillomavirus (HPV) 16 infection is an important factor for cervical cancer. Alteration in local levels of TNF in the cervix may affect the immune response of an individual, hence affecting the persistence of HPV. Excess TNF-α can result in harmful inflammatory responses, whereas too little

can contribute to persistent infection. TNF-α is one of the primary cytokines released after HPV infection and upregulates the expression of antigen-processing and presentation pathway components for class I HLA. Eleven TNF SNPs were associated with susceptibility to HPV16-associated cervical cancer. A significant difference in genotype distribution of three SNPs between the cases and controls were reported. Haplotype distribution also showed a significant difference between cases and controls. A new association was reported between several TNF-SNPs and susceptibility to cervical cancer [68]. The associations between six TNF SNPs (rs1799964, rs1800630, rsl799724, rs1800629, rs361525 and rs1800610) and prostate cancer risk were investigated [69].