Significant increases of blood flow to exercising muscles may provide training benefits for some athletes during certain types of competition or physical conditioning. For example, this website the high degree of leg pump might provide unique athletic conditioning benefits to those in the competitive bodybuilding field and others during particular phases of training. Conclusion Chronic supplementation of GPLC appears to provide benefits
that are dose dependent. While acute supplementation of 4.5 grams was previously shown to provide significant enhancement of anaerobic work capacity, the present study suggests that chronic supplementation of GPLC at 3.0 or 4.5 grams daily does not improve anaerobic performance of repeated high speed high intensity bouts and may actually produce detrimental effects with high velocity, high intensity exercise. However, these results also suggest that 1.5 g GPLC does provide enhancement of anaerobic capacity. These findings also suggest that long term supplementation with this dosage (1.5 g/day) results in significantly lower lactate accumulation with high intensity exercise.
Acknowledgements Funding for this work was provided by Sigma-tau HealthSciences, Inc. References 1. Hamman JJ, Kluess HA, Buckwalter JB, Clifford PS: Blood flow GANT61 price response to muscle contractions is more closely related to metabolic rate than contractile work. J Appl Physiol 2005, 98:2096–2100.CrossRef 2. Tschakovsky ME, Joyner MJ: Nitric oxide and muscle blood flow in exercise. Appl Physiol Nutr Metab 2007, 33:151–161.CrossRef 3. Adams MR, Forsyth CJ, Jessup mTOR inhibitor W, Robinson
J, Celermajer DS: Oral arginine inhibits platelet aggregation but does not enhance endothelium-dependent dilation in healthy young men. J Amer Col Cardiology 1995, 26:1054–1061.CrossRef 4. Bode-Boger SM, Boger RH, Galland A, Tsikas D, Frolich J: L-arginine-induced vasodilation in healthy humans: pharmacokinetic-pharmacodynamic Telomerase relationship. Br J Clin Pharmacol 1998, 46:489–497.CrossRefPubMed 5. Chin-Dusting JP, Alexander CT, Arnold PJ, Hodgson WC, Lux AS, Jennings GI: Effects of in vivo and in vitro L-arginine supplementation on healthy human vessels. J Cardiovasc Pharmacol 1996, 28:158–166.CrossRefPubMed 6. Bloomer RJ, Tschume LC, Smith WA: Glycine propionyl-L-carnitine modulates lipid peroxidation and nitric oxide in human subjects. Int J Vitam Nutr Res 2009, 79:131–41.CrossRefPubMed 7. Bloomer RJ, Smith WA, Fisher-Wellman KH: Glycine propionyl-L-carnitine increases plasma nitrate/nitrite in resistance trained men. J Int Soc Sports Nutr 2007,4(1):22.CrossRefPubMed 8. Jacobs PL, Goldstein ER, Blackburn W, Orem I, Hughes JJ: Glycine propionyl-L-carnitine produces enhanced anaerobic work capacity with reduced lactate accumulation in resistance trained males. J Int Soc Sports Nutr 2009, 6:9.CrossRefPubMed 9. Anderson P, Saltin B: Maximal perfusion of skeletal muscle in man.