“
“These guidelines were developed before the uptake of the GRADE framework by the KHA-CARI Guidelines organization. Accordingly, the writers have followed an adapted version of the NHMRC evidence rating

system published in 1999.[1] A description of the ratings applied to the evidence is shown in Table 1. Guideline Recommendations are based on Level I or II evidence and Suggestions for Clinical Care are based on Level III or IV evidence. This guideline addresses issues relevant to the development, prevention and management of peritonitis and catheter-related infections in peritoneal dialysis patients. Recurrent or severe exit site infections (ESI) and peritonitis are a problem with peritoneal dialysis (PD) and represent the major causes of Tenckhoff catheter removal and PD technique failure. Peritonitis is the most common complication of PD. Up KPT-330 ic50 to one-third of all PD peritonitis episodes lead to hospitalization[2] and 5–10% of cases IWR-1 nmr end in patient death.[3] ESI are associated with a greatly increased risk of subsequent peritonitis and when ESI and peritonitis occur together, catheter removal occurs in approximately 50% of cases.[4] Disconnect systems of continuous ambulatory peritoneal dialysis (CAPD) result in lower rates of peritonitis than ‘spike’

systems and this older system should no longer be used (Evidence level I). Twin bag systems have lower rates of peritonitis than Y-disconnect systems and are recommended as the preferred CAPD technique (Evidence level I). There is insufficient high level evidence (one adequate small RCT only) to support a difference in peritonitis rates when biocompatible fluids are used compared with standard dextrose solutions in PD patients (Evidence level II). The choice of APD or CAPD

regimens in PD patients should not be influenced by a possible effect on peritonitis rates. The choice of conventional or biocompatible PD solutions should not be unduly influenced by potential benefits in peritonitis rates until stronger evidence becomes available. In peritoneal dialysis patients with a provisional diagnosis Selleckchem Sirolimus of peritonitis, treatment should commence with a combination of intraperitoneal antibiotics that will adequately cover Gram-positive and Gram-negative organisms. Once bacterial diagnosis is made, then a change to appropriate antibiotic should be made. Treatment should be of adequate duration to reduce recurrence (Evidence level II). Where local or international guidelines are available they should be used to guide therapy. Peritoneal dialysate effluent should be collected and processed in appropriate manner to ensure culture-negative episodes account for <20% of all PD-associated peritonitis. While there is no good evidence to support specific antibiotic choice, empiric intraperitoneal therapy should consider local microbiological resistance profiles and cover Gram-positive and Gram-negative bacteria.