17,18 These regions are also activated in mood induction paradigms, attcntional and memory tasks, and during conditions of hunger and satiety,19-21 and may be related to the cognitive and vegetative, in addition to mood, symptoms. The cortical hypermetabolism may be a compensatory mechanism for neurodegenerative changes such as amyloid deposition or neuroinflammation, or may be the
result of a primary or secondary increase in glutamate concentrations as glutamate is the primary neurotransmitter with these cortico-cortical pathways.22 Serotonin Inhibitors,research,lifescience,medical transporter occupancy and treatment response While studies of cerebral glucose metabolism provide invaluable information regarding changes in neural circuitry, PET neuroreceptor radiotracers can be applied to evaluate the neurochemical substrates of the cerebral metabolic effects observed. The serotonin transporter is a logical initial target, as this is the primary binding site of the SSRIs, and the serotonin transporter is located in cortical, striatal, and limbic regions Inhibitors,research,lifescience,medical shown to be affected by {TNF-alpha inhibitor|TNF alpha inhibitor|TNF-alpha inhibitor|TNF alpha inhibitor|TNF-alpha inhibitor|TNF alpha inhibitor|TNF-alpha inhibitor|TNF alpha inhibitor|TNF-alpha inhibitor|TNF alpha inhibitor|TNF-alpha inhibitor|TNF alpha inhibitor|TNF-alpha inhibitor|TNF alpha inhibitor|TNF-alpha inhibitor|TNF alpha inhibitor|TNF-alpha inhibitor|TNF alpha inhibitor|TNF-alpha inhibitor|TNF alpha inhibitor|TNF-alpha inhibitor|TNF alpha inhibitor|TNF-alpha inhibitor|TNF alpha inhibitor|TNF-alpha inhibitor|TNF alpha inhibitor|TNF-alpha inhibitor|TNF alpha inhibitor|TNF-alpha inhibitor| buy TNF-alpha inhibitor|TNF-alpha inhibitor ic50|TNF-alpha inhibitor price|TNF-alpha inhibitor cost|TNF-alpha inhibitor solubility dmso|TNF-alpha inhibitor purchase|TNF-alpha inhibitor manufacturer|TNF-alpha inhibitor research buy|TNF-alpha inhibitor order|TNF-alpha inhibitor mouse|TNF-alpha inhibitor chemical structure|TNF-alpha inhibitor mw|TNF-alpha inhibitor molecular weight|TNF-alpha inhibitor datasheet|TNF-alpha inhibitor supplier|TNF-alpha inhibitor in vitro|TNF-alpha inhibitor cell line|TNF-alpha inhibitor concentration|TNF-alpha inhibitor nmr|TNF-alpha inhibitor in vivo|TNF-alpha inhibitor clinical trial|TNF-alpha inhibitors|TNF-alpha signaling inhibitor|TNF-alpha pathway inhibitor|TNF-alpha signaling pathway inhibitor|TNF-alpha signaling inhibitors|TNF alpha pathway inhibitors|TNF-alpha signaling pathway inhibitors|TNF-alpha inhibitor library|TNF-alpha activity inhibition|TNF-alpha activity|TNF-alpha inhibition|TNF-alpha inhibitors library|TNF alpha inhibitor libraries|TNF-alpha inhibitor screening library|TNF-alpha high throughput screening|TNF-alpha inhibitors high throughput screening|TNF-alpha phosphorylation|TNF-alpha screening|TNF-alpha assay|TNF-alpha animal study| citalopram and related to treatment response. Neuroimaging
studies of the serotonin transporter have been performed mainly Inhibitors,research,lifescience,medical in midlife depressed patients. Reduced serotonin transporter binding in the midbrain (including the raphe nuclei) has been reported in midlife depressed patients.23 In one of the initial studies of the effects of SSRI treatment (paroxetine and citalopram) on serotonin transporter binding, Meyer Inhibitors,research,lifescience,medical et al24observed a high degree of serotonin transporter occupancy at relatively low SSRI plasma concentrations. Serotonin transporter occupancy by citalopram has been studied in patients Inhibitors,research,lifescience,medical with geriatric depression.25 Seven patients underwent studies with the selective serotonin transporter radiotracer [11CJ-DASB developed by Wilson and colleagues.26 The patients demonstrated 70% occupancy by citalopram in the striatum and thalamus, which was not correlated with the change in depression ratings over the treatment
interval, in addition to citalopram dose and plasma concentration. Exploratory, voxelwise analyses revealed that the magnitude of serotonin transporter occupancy by citalopram was observed in regions in which significant decreases (anterior cingulate, middle frontal gyrus, superior and middle Methisazone temporal gyrus, precuneus) and increases (inferior parietal lobule, cuneus) in cerebral glucose metabolism have been observed. The [11C]-DASB images from a representative subject are shown in (Figure 2).These results indicate that serotonin transporter occupancy in cortical regions, which can be measured using higher-resolution PET scanners implemented in the past decade, may be relevant to the clinical and cerebral metabolic effects of citalopram in geriatric depressed patients. Figure 2.