81 A second study examined the impact of enzalutamide mechanism of action depression in 1600 patients with diabetes who were still working partor full-time.82 Depressive illness and diabetic symptoms were associated with greater work disability, including missing 5 or more days of work in the prior month and severe difficulty performing work tasks.82

Cross-sectional studies of patients with CHD and CHF have also shown that comorbid depression is associated with additive functional impairment.83,84 Because it is unclear whether decreased functioning causes depression Inhibitors,research,lifescience,medical or whether this Inhibitors,research,lifescience,medical affective illness leads to functional decline, studies have begun to utilize longitudinal designs. Longitudinal studies in aging populations have described a bidirectional relationship between depression and functional impairment.85-89 Functional impairment in aging populations predicts depression and, conversely, major depression and depressive symptoms have

been found to be risk factors for progression of disability.85-88 Studies by Van Korff and colleagues90 and Ormel et al91 have also shown that depressive symptoms and disability measures change synchronously over time – as depression improves, Inhibitors,research,lifescience,medical so do measures of functional impairment. Prospective studies in both cardiology and primary care settings have shown comorbid depression in patients with CHF and CHD can be more predictive Inhibitors,research,lifescience,medical of functional impairment over time than is severity of physical illness. Sullivan and colleagues80 showed that in 113 patients with CHF in a specialty cardiology Inhibitors,research,lifescience,medical clinic that comorbid depression was prospectively associated with decreased distance on the 6-minute walk as well as decreased

self-reported functioning on generic and disease-specific measures of function (Kansas City Cardiomyopathy Questionnaire92) after controlling for demographic and clinical characteristics GSK-3 (such as left ventricular ejection fraction). A primary care-based study showed that over a 6-month period after controlling for severity of cardiac AZD9291 disease, comorbid depression in 139 patients with CHF was associated with significant and persistent adverse effects on perception of health, impairment on the Kansas City Cardiomyopathy Questionnaire, physical limitations, role function, and quality of life compared with patients with CHF alone.93 Depression was also shown to be the strongest predictor of functional decline in a prospective study of patients with heart failure.