(Surg Obes Relat Dis 2010;6:373-376.) (C) 2010 American Society for Metabolic and Bariatric Surgery. All rights reserved.”
“The identification of cervical cancer patients at high risk of local recurrence is urgent to improve the selection of patients for more aggressive treatment. The immune contexture in human tumors has vital impact on clinical outcome. Our aim in the study was to establish a predictive model of local recurrence by assessing the prognostic significance of clinicopathologic features and five immune markers within the tumor microenvironment in cervical cancer. The
expression of CD3, CD4, CD8, FoxP3, and IL-17 was assessed by immunohistochemistry in tumor tissue Ruboxistaurin cost from 153 patients after radical resection for cervical cancer. Prognostic effects
of these immune markers and clinicopathologic factors were evaluated by Kaplan-Meier and Cox regression analysis. Local recurrence was observed in 34 % patients (52/153). Independent predictors of tumor recurrence were lymph node status (P = 0.004), lymph-vascular space invasion (P = 0.012), and the number of intratumoral IL-17(+) cells (P = 0.003). Selleckchem C59 The risk of local recurrence was the highest in patients with lymph node positivity, presence of lymph-vascular space invasion, and low prevalent of intratumoral IL-17(+) cells (probability, 73 %; 5-year DFS, 19 %). A Cox model composed of these three features provided a significant higher diagnostic accuracy of local recurrence than each feature alone (P smaller than 0.05). Lymph node status, lymph node space invasion, and number of intratumoral IL-17(+) cells are three independent predictors for recurrence of cervical cancer. Their combination by a Cox model is highly predictive and may help to identify high-risk patients who may benefit from adjuvant chemotherapy.”
“The consumption of fruit and vegetables continues to rise in the United States and European Union due
to healthy lifestyle recommendations. Meanwhile, the rate of foodborne illness caused by the consumption of these products remains high in both regions, representing a significant public health and financial issue. This study addresses the occurrence of reported foodborne outbreaks associated with fresh fruits and vegetables consumption in the United States and European Union during the period 2004-2012, where data are available. Special attention is paid LY294002 price to those pathogens responsible for these outbreaks, the mechanisms of contamination, and the fresh produce vehicles involved. Norovirus is shown to be responsible for most of the produce-related outbreaks, followed by Salmonella. Norovirus is mainly linked with the consumption of salad in the United States and of berries in the European Union, as demonstrated by the Multiple Correspondence Analysis (MCA). Salmonella was the leading cause of multistate produce outbreaks in the United States and was the pathogen involved in the majority of sprouts-associated outbreaks.