The study of intestinal permeability can provide important
information regarding changes in the structure and function of the mucosal barrier after the procedure.
The urinary excretion rates of lactulose and mannitol after oral intake of both substances were evaluated. We also evaluated the MK-8776 in vitro lactulose/mannitol excretion ratio. Tests were performed during the preoperative period (T0), at the first postoperative month (T1), and at the sixth postoperative month (T6).
The study included 16 morbidly obese patients. The excretion rate of mannitol was significantly lower at T1 compared with T0 and T6 (p = 0.003). There was no significant difference in the excretion rates of lactulose or in the lactulose/mannitol ratio during the three periods. Six patients (37.5 %) exhibited a considerable increase in the excretion rate of lactulose at T6 (4-73 times higher than the preoperative value), accompanied by proportional variations in the lactulose/mannitol ratio.
The significant increase in mannitol excretion rate from T1 to T6 most likely reflects the occurrence of intestinal adaptation (mucosal hyperplasia), which would tend to
minimize the malabsorption of macronutrients. A subgroup of patients who undergo RYGB exhibit pronounced increase AS1842856 mouse in their intestinal permeability (assessed by the lactulose/mannitol ratio and the lactulose excretion rate) at T6.”
“Background: EVLA has proven to be very successful, but the optimum methods for energy delivery have still not been clarified. A better understanding of the mechanism of action may contribute
to achieving a consensus on the best laser method and the most effective use of laser parameters, resulting in optimal clinical outcomes, maintaining high success rates with minimal adverse events. The aim of this study is to assess the impact of wavelength, pullback speed and power level on the endovenous temperature profile in an experimental setting.
Methods: In an experimental setting, temperature measurements were performed using thermocouples. ABT-263 nmr The experimental set-up consisted of a transparent box in which a glass tube was fixed. Different laser parameters (wavelength and power) and 2 different pullback speeds (2 and 5 mm/s) were used. Thermocouples were placed at different distances from the fiber tip. Validity of the experimental setting was assessed by performing the same temperature measurements using a stripped varicose vein. The maximal temperature rise and the time span that the temperature was above collagen denaturation temperature were measured.
Results: The experiments showed that decreasing the pullback speed (2 mm/s) and increasing the power (up to 14 W) both cause higher maximal temperature and a longer time above the temperature for collagen denaturation. The use of different laser wavelengths (940 or 1470 nm) did not influence the temperature profile.