These results suggested that the PI3K/Akt inhibitor LY294002 can enhance chemosensitivity of human gastric cancer to vincristine. This preclinical evaluation of a rational Belnacasan in vitro combination of LY294002 and vincristine may provide a new strategy to resolve the multidrug resistance of gastric cancer. Key Word(s): 1. PI3K/Akt; 2. chemosensitivity; 3. gastric cancer; 4. vincristine; Presenting Author: GUODONG CHEN Additional Authors: YULAN LIU Corresponding Author: GUODONG CHEN Affiliations: Department of Gastroenterology, Peking University
People’s Hospital Objective: Primary gastric lymphoma (PGL) is the most common extranodal lymphoma while diffuse large B-cell lymphoma (DLBCL) is the main histological subtype. The therapeutic efficacy and outcome of DLBCL have not been well defined. This study aimed to analyze the therapeutic efficacy of surgery, chemotherapy and the combination of chemotherapy with surgery for DLBCL. Methods: All the cases satisfied the PGL diagnosis criteria defined by Dawson. The stage of the disease was determined according to the Ann Arbor criteria proposed for gastrointestinal lymphoma. Clinical features of 30 Chinese patients (stage I and II) with newly diagnosed gastrointestinal DLBCL were retrospectively analyzed. Therapeutic outcomes were compared
between different treatment groups. Survival curves selleck products and the univariate analysis were analyzed by the Kaplan-Meier method. Results: Of the 30 patients recruited into the study, 20 were male and 10 were female with a median age of 65 years (range 29–80 years). 13 patients (43 %) received chemotherapy, 5 years survival rate was 53.8%, 6 patients (20 %) received surgery, 5 years survival rate was 65.9%, 11 patients (37 %) received the combination of chemotherapy with surgery, this treatment attain 63.6% 5 year survival rate. There was no significant difference in survival curves among chemotherapy only, surgery only and the combination of chemotherapy 上海皓元 with surgery (p > 0.1). Surgery and the combination of chemotherapy did not provide a significant
survival benefit for patients. Conclusion: Chemotherapy should be the first-line therapy procedure for DLBCL. As the traditional treatment, surgery will not be classic therapy for DLBCL. Key Word(s): 1. DLBCL; 2. Therapeutic Efficacy; Presenting Author: XIAOMEI ZHANG Additional Authors: CHAO YANG, HAIXU CHEN, BENYAN WU Corresponding Author: CHAO YANG, BENYAN WU Affiliations: General Hospital of Chinese PLA; Institute of Gerontology and Geriatrics; Department of Gastroenterology & Hepatology; Department of Gerontal Gastroenterology Objective: Radiation-induced gastrointestinal syndrome (RIGS) is a common complication in radiotherapy for solid organ malignancies in abdomen or pelvis. However, currently there are no approved medical countermeasures for RIGS. We aimed to study the therapy effect of cytokines treated Flk-1+MSCs on RIGS.