Schwarzenbach H, Chakrabarti G, Paust HJ, Mukhopadhyay AK: Gonadotropin-mediated regulation of the murine VEGF expression in MA-10 Leydig cells. J Androl 2004, 25 (1) : 128–139.PubMed 37. Jones A, Fujiyama C, Turner K, Fuggle S, Cranston D, Turley H, Valtola R, Bicknell R, Harris AL: Angiogenesis and lymphangiogenesis in stage 1 germ cell tumours of the testis. BJU Int 2000, 86 (1) : 80–86.CrossRefPubMed 38. Wulff C, Wilson H, Largue P, Duncan WC, Armstrong DG, Fraser HM: Angiogenesis in the human corpus luteum: localization and changes in angiopoietins, tie-2, and vascular endothelial growth factor messenger ribonucleic acid. J Clin Endocrinol Metab 2000, 85: 4302–4309.CrossRefPubMed 39. Haggstrom

Rudolfsson S, Johansson A, Franck Lissbrant I, Wikstrom P, Bergh A: Localized expression of angiopoietin 1 and 2 may explain unique characteristics of the rat testicular microvasculature. Biol Reprod 2004, 69: 1231–1237.CrossRef 40. Aigner A, Brachmann Staurosporine in vivo P, Beyer J, Jäger R, Raulais D, Vigny M, Neubauer A, Heidenreich A, Weinknecht S, Czubayko F, Zugmaier G: Marked increase of the growth factors pleiotrophin and fibroblast growth factor-2 in serum of testicular cancer patients. Ann Oncol 2003, 14 (10) : 1525–1529.CrossRefPubMed 41. Reisinger K, Baal N, McKinnon T, Mûnsteed K, Zygmunt M: The gonadotropins: find protocol tissue-specific

angiogenic factors? Mol Cell Endocrinol 2007, 269 (1–2) : 65–80.CrossRefPubMed Competing interests The authors declare that they have no competing interests. Authors’ contributions OA design and conception of the study, analysis of data, revision of the

manuscript, RMM acquisition and analysis of data, draft and revision of the manuscript, JAS acquisition of data, CVG critically revised the manuscript and also contributed to the analysis, AAS supervised the immunohistochemistry, revised the manuscript, JGCV checked the immunohistochemistry, revised the final version, EAO revised the data, ALG carried out the immunohistochemistry, MAJ critical revision of the manuscript and JLA conception of the study and revision of the manuscript. All authors have read and approved the final version of the manuscript.”
“Background Soft Tissue Trichostatin A clinical trial Sarcomas (STS) are malignant tumors that develop within mesenchymal connective tissue and can occur in any Mirabegron part of the body, most commonly in the limbs, which represent over 45% of occurrences [1]. STS growth does not usually cause any noticeable symptoms in early stages, making early detection uncommon. Some STS such as synovial sarcoma, malignant fibrous histiocytoma, rhabdomyosarcoma and certain neurogenic sarcomas tend to invade peripheral tissues, such as nerves, vessels and bones, and are thus have a relatively poor prognosis and are difficult to cure [2]. The treatment of limb STS have traditionally included surgery, which can involve extensive muscle excision or resection [3].